References: 1. BRAAM, W., DIDDEN, R., SMITS, M. G. & CURFS, L. M. (2008). Melatonin for chronic insomnia in Angelman syndrome: a randomized placebo-controlled trial. J Child Neurol, 23, 649-654.; 2. BRUNI, O., CORTESI, F., GIANNOTTI, F. & CURATOLO, P. (1995). Sleep disorders in tuberous sclerosis: a polysomnographic study. Brain Dev, 17, 52-56.; 3. CARR, R., WASDELL, M. B., HAMILTON, D., WEISS, M. D., FREEMAN, R. D., TAI, J., RIETVELD, W. J. & JAN, J. E. (2007). Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. J Pineal Res, 43, 351-359.; 4. DE LEERSNYDER, H. (2006). Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment. Trends Endocrinol Metab, 17, 291-298.; 5. DE LEERSNYDER, H., DE BLOIS, M. C., BRESSON, J. L., SIDI, D., CLAUSTRAT, B. & MUNNICH, A. (2003). [Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome]. Rev Neurol (Paris), 159, 6S21-26.; 6. DE LEERSNYDER, H., DE BLOIS, M. C., CLAUSTRAT, B., ROMANA, S., ALBRECHT, U., VON KLEIST-RETZOW, J. C., DELOBEL, B., VIOT, G., LYONNET, S., VEKEMANS, M. & MUNNICH, A. (2001a). Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome. J Pediatr, 139, 111-116.; 7. DE LEERSNYDER, H., DE BLOIS, M. C., VEKEMANS, M., SIDI, D., VILLAIN, E., KINDERMANS, C. & MUNNICH, A. (2001b). beta(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome. J Med Genet, 38, 586-590.; 8. DE LEERSNYDER, H., ZISAPEL, N. & LAUDON, M. (2011). Prolonged-release melatonin for children with neurodevelopmental disorders. Pediatr Neurol, 45, 23-26.

ELSEA, S. H. & GIRIRAJAN, S. (2008). Smith-Magenis syndrome. Eur J Hum Genet, 16, 412-421.; 9. NORD (2024) Smith Magenis Syndrome. https://rarediseases.org/rare-diseases/smith-magenis-syndrome; 10. NORD (2023) Tuberous Sclerosis Complex.https://rarediseases.org/rare-diseases/tuberous-sclerosis.; 11. NORD (2008) Williams Syndrome. https://rarediseases.org/rare-diseases/williams-syndrome.; 12. GRINGRAS, P., NIR, T., BREDDY, J., FRYDMAN-MAROM, A. & FINDLING, R. L. (2017). Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder. Journal of the American Academy of Child & Adolescent. Psychiatry, 56, 948-957.e944.; 13. GROPMAN, A. L., DUNCAN, W. C. & SMITH, A. C. (2006). Neurologic and developmental features of the Smith-Magenis syndrome (del 17p11.2). Pediatr Neurol, 34, 337-350.; 14. HANCOCK, E., O'CALLAGHAN, F., ENGLISH, J. & OSBORNE, J. P. (2005a). Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin. J Child Neurol, 20, 21-25.; 15. HANCOCK, E., O'CALLAGHAN, F. & OSBORNE, J. P. (2005b). Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. J Child Neurol, 20, 78-80.; 16. JAN, J. E., BAX, M. C., OWENS, J. A., IPSIROGLU, O. S. & WASDELL, M. B. (2012). Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities. Eur J Paediatr Neurol, 16, 403-412.; 17. JAN, J. E., HAMILTON, D., SEWARD, N., FAST, D. K., FREEMAN, R. D. & LAUDON, M. (2000). Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders. J Pineal Res, 29, 34-39.; 18. MARTENS, M. A., SEYFER, D. L., ANDRIDGE, R. R. & COURY, D. L. (2017). Use and Effectiveness of Sleep Medications by Parent Report in Individuals with Williams Syndrome. J Dev Behav Pediatr, 38, 765-771.; 19. MARTENS, M. A., WILSON, S. J. & REUTENS, D. C. (2008). Research Review: Williams syndrome: a critical review of the cognitive, behavioral, and neuroanatomical phenotype. J Child Psychol Psychiatry, 49, 576-608.; 20. MCARTHUR, A. J. & BUDDEN, S. S. (1998). Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment. Dev Med Child Neurol, 40, 186-192.; 21. MIYAMOTO, A., OKI, J., TAKAHASHI, S. & OKUNO, A. (1999). Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. Brain Dev, 21, 59-62.; 22. MORRIS, C., JANSSENS, A., SHILLING, V., ALLARD, A., FELLOWES, A., TOMLINSON, R., WILLIAMS, J., THOMPSON COON, J., ROGERS, M., BERESFORD, B., GREEN, C., JENKINSON, C., TENNANT, A. & LOGAN, S. (2015). Meaningful health outcomes for paediatric neurodisability: Stakeholder prioritisation and appropriateness of patient reported outcome measures. Health Qual Life Outcomes, 13, 87.; 23. NORD (2015). Rett Syndrome. https://rarediseases.org › Rare Diseaseshttps://rarediseases.org/rare-diseases/rett-syndrome; 24. NORD (2018). Angelman Syndrome. https://rarediseases.org/rare-diseases/angelman-syndrome; 25. PAPROCKA, J., KIJONKA, M., WOJCIESZEK, P., PECKA, M., EMICH-WIDERA, E. & SOKOL, M. (2017). Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion. Int J Endocrinol, 2017, 5853167.; 26. REILLY, C., SENIOR, J. & MURTAGH, L. (2015). ASD, ADHD, mental health conditions and psychopharmacology in neurogenetic syndromes: parent survey. J Intellect Disabil Res, 59, 307-318.; 27. SNIECINSKA-COOPER, A. M., ILES, R. K., BUTLER, S. A., JONES, H., BAYFORD, R. & DIMITRIOU, D. (2015a). Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome. Sleep Med, 16, 94-100.; 28. SNIECINSKA-COOPER, A. M., ILES, R. K., BUTLER, S. A., JONES, H., BAYFORD, R. & DIMITRIOU, D. (2015b). Response to the letter "Sleep characteristics of children with Williams syndrome in relation to saliva melatonin and cortisol". Sleep Med, 16, 1177.; 29. STROMME, P., BJORNSTAD, P. G. & RAMSTAD, K. (2002). Prevalence estimation of Williams syndrome. J Child Neurol, 17, 269-271.; 30. WILLIAMS, C. A., BEAUDET, A. L., CLAYTON-SMITH, J., KNOLL, J. H., KYLLERMAN, M., LAAN, L. A., MAGENIS, R. E., MONCLA, A., SCHINZEL, A. A., SUMMERS, J. A. & WAGSTAFF, J. (2006). Angelman syndrome 2005: updated consensus for diagnostic criteria. Am J Med Genet A, 140, 413-418.; 31. WILLIAMS, C. A., DRISCOLL, D. J. & DAGLI, A. I. (2010). Clinical and genetic aspects of Angelman syndrome. Genet Med, 12, 385-395.; 32. YOUNG, D., NAGARAJAN, L., DE KLERK, N., JACOBY, P., ELLAWAY, C. & LEONARD, H. (2007). Sleep problems in Rett syndrome. Brain Dev, 29, 609-616.; 33. O'Callaghan, F. J., Clarke, A. A., Hancock, E., Hunt, A., & Osborne, J. P. (1999). Use of melatonin to treat sleep disorders in tuberous sclerosis. Dev Med Child Neurol, ;41(2):123-126.; 34. Zhdanova, I. V., Wurtman, R. J., & Wagstaff, J. (1999). Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J Pediatr Endocrinol Metab, Jan-Feb;12(1):57-67.